Experiential Modification of the Trigeminal Reflex Blink Circuit

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Experiential modification of the trigeminal reflex blink circuit.

To characterize the organization and plasticity of the trigeminal reflex blink circuit, we interacted blink-evoking supraorbital (SO) and infraorbital (IO) nerve stimuli in alert rats. Stimulation of either trigeminal branch produced a short-lasting inhibition followed by a longer-lasting facilitation of blinks evoked by stimulating the other nerve. When IO stimulation evoked a smaller blink th...

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Enhanced long-term potentiation-like plasticity of the trigeminal blink reflex circuit in blepharospasm.

Benign essential blepharospasm (BEB) is a focal cranial dystonia affecting eye closure. Here, we tested the hypothesis that BEB is associated with abnormal plasticity of the neuronal circuits mediating reflex blinks. In patients with BEB and healthy age-matched controls, we used the conditioning protocol introduced by Mao and Evinger (2001) to induce long-term potentiation (LTP)-like plasticity...

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Trigeminal high-frequency stimulation produces short- and long-term modification of reflex blink gain.

Reflex blinks provide a model system for investigating motor learning in normal and pathological states. We investigated whether high-frequency stimulation (HFS) of the supraorbital branch of the trigeminal nerve before the R2 blink component (HFS-B) decreases reflex blink gain in alert rats. As with humans (Mao JB, Evinger C. J Neurosci 21: RC151, 2001), HFS-B significantly reduced blink size ...

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Trigeminal High Frequency Stimulation Produces Short - and Long - Term Modification 4 of Reflex Blink Gain 5 Abbreviated Title : Modifying Reflex Blink Gain

37 Reflex blinks provide a model system for investigating motor learning in normal and 38 pathological states. We investigated whether high frequency stimulation of the supraor39 bital branch of the trigeminal nerve before the R2 blink component (HFS-B) decreases 40 reflex blink gain in alert rats. As with humans (Mao and Evinger 2001), HFS-B signifi41 cantly reduced blink size in the first hou...

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The human blink reflex.

A detailed study of the human blink reflex in the different parts of the orbicularis oculi muscle has been carried out. The first component of the blink reflex has been demonstrated in patients with Friedreich's ataxia, who have selective loss of large sensory fibres resulting in loss of proprioceptive input. It has been established that both components of the blink reflex are cutaneous reflexe...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2007

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1152-07.2007